Treatment and prevention of trichomoniasis, bacterial vaginosis and candidiasis with a new 7-day regime containing metronidazole and miconazole in a single vaginal pessary

IJMDAT 2018; 1 (1): e118

  Topic: Gynecology     Category:

Abstract

Objective: To evaluate the efficacy of a new pessary combination of metronidazole 750 mg + miconazole nitrate 200 mg in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections.
Patients and Methods: 104 patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary once daily for seven days. Gynecological and microbiological assessments were carried out before and 8-10 and 21-23 days after the start of treatment.
Results: Vaginitis symptoms were resolved in 97% of the 99 patients evaluated, and improved in the remaining 3%. Microbiological cure rates were 100% for trichomoniasis, 96.2% for bacterial vaginosis and 90% for candidiasis. Recurrence rates were 2.7%, 5.7% and 15.3%, respectively. The overall microbiological cure rate for mixed infections was 92%, with 97% for trichomonal + bacterial and 80% for bacterial + candidal vaginitis. In 2 out of 2 cases each with trichomonal + candidal and trichomonas l + bacterial + candidal infection, the microorganisms were eradicated completely.
Conclusions: Metronidazole and miconazole in a dosage of 750 mg + 200 mg respectively as a single pessary provide immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain. This medical approached represents an improvement in the management of these diseases as effective and improved compliance rates are achieved with this new dosage regime.

To cite this article

Treatment and prevention of trichomoniasis, bacterial vaginosis and candidiasis with a new 7-day regime containing metronidazole and miconazole in a single vaginal pessary

IJMDAT 2018; 1 (1): e118

Publication History

Submission date: 13 Feb 2017

Revised on: 16 Feb 2017

Accepted on: 02 Aug 2017

Published online: 27 Mar 2018