Riboflavin deficiency increases body weight and fat deposition and decreases Glucose Transporter Type 4 (GLUT-4) and Glucokinase (GCK) expression. Cobalamin deficiency inhibits the conversion of methylmalonic acid (MMA) to succinyl-coA, causing MMA overload and consequent induction of lipogenesis and insulin resistance; in addition, it reduces the methylation of homocysteine to methionine, causing the accumulating of homocysteine which further enhances insulin resistance. Both riboflavin and cobalamin may prevent the onset of Gestational Diabetes Mellitus (GDM) in pregnant women.
To cite this article
Effects of riboflavin and cobalamin levels on maternal metabolic homeostasis: a possible strategy to prevent gestational diabetes mellitus?
IJMDAT 2018; 1 (1): e120
Submission date: 06 Jun 2017
Revised on: 04 Jul 2017
Accepted on: 20 Nov 2018
Published online: 27 Mar 2018
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.